diff --git a/pkgs/by-name/li/libheif/package.nix b/pkgs/by-name/li/libheif/package.nix
index 7d4912e77598..a24d7986b884 100644
--- a/pkgs/by-name/li/libheif/package.nix
+++ b/pkgs/by-name/li/libheif/package.nix
@@ -24,7 +24,7 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "libheif";
-  version = "1.21.2";
+  version = "1.22.2";
 
   outputs = [
     "bin"
@@ -38,7 +38,7 @@ stdenv.mkDerivation (finalAttrs: {
     owner = "strukturag";
     repo = "libheif";
     rev = "v${finalAttrs.version}";
-    hash = "sha256-odkJ0wZSGoZ7mX9fkaNREDpMvQuQA9HKaf3so1dYrbc=";
+    hash = "sha256-z5vTfZATfwDn8Zwqt3piS7PaOQQ3UG+u20sR6j+dsUg=";
   };
 
   nativeBuildInputs = [
diff --git a/pkgs/development/python-modules/pillow-heif/default.nix b/pkgs/development/python-modules/pillow-heif/default.nix
index eea442596817..cc00832bb662 100644
--- a/pkgs/development/python-modules/pillow-heif/default.nix
+++ b/pkgs/development/python-modules/pillow-heif/default.nix
@@ -77,6 +77,17 @@ buildPythonPackage rec {
   disabledTests = [
     # Time sensitive speed test, not reproducible
     "test_decode_threads"
+    # Tests failing with libheif 1.22.0. To be removed in the next release
+    # https://github.com/bigcat88/pillow_heif/issues/424
+    # these check what happens when the ispe is not valid
+    "test_numpy_array_invalid_ispe"
+    "test_allow_incorrect_headers"
+    "test_invalid_ispe_ok"
+    "test_invalid_ispe_allow"
+    "test_invalid_ispe_stride"
+    "test_invalid_ispe_stride_pillow"
+    # disable version check for libheif
+    "test_libheif_info"
   ]
   ++ lib.optionals stdenv.hostPlatform.isDarwin [
     # https://github.com/bigcat88/pillow_heif/issues/89