diff --git a/pkgs/development/python-modules/numba/default.nix b/pkgs/development/python-modules/numba/default.nix
index 506f0e10dfd6..0e38f0392cde 100644
--- a/pkgs/development/python-modules/numba/default.nix
+++ b/pkgs/development/python-modules/numba/default.nix
@@ -37,7 +37,7 @@ let
   cudatoolkit = cudaPackages.cuda_nvcc;
 in
 buildPythonPackage (finalAttrs: {
-  version = "0.63.1";
+  version = "0.65.1";
   pname = "numba";
   pyproject = true;
 
@@ -53,7 +53,7 @@ buildPythonPackage (finalAttrs: {
     postFetch = ''
       sed -i 's/git_refnames = "[^"]*"/git_refnames = " (tag: ${finalAttrs.src.tag})"/' $out/numba/_version.py
     '';
-    hash = "sha256-M7Hdc1Qakclz7i/HujBUqVEWFsHj9ZGQDzb8Ze9AztA=";
+    hash = "sha256-DMmUyTElDFyMK4BUQ4EhDNmG43lOWQHurKbnSyhAs5k=";
   };
 
   postPatch = ''
@@ -84,25 +84,7 @@ buildPythonPackage (finalAttrs: {
     llvmlite
   ];
 
-  patches = [
-    # Support Numpy 2.4, see:
-    #
-    # - https://github.com/numba/numba/pull/10393
-    # - https://github.com/numba/numba/issues/10263
-    (fetchpatch {
-      url = "https://github.com/numba/numba/commit/7ec267efb80d87f0652c00535e8843f35d006f20.patch";
-      hash = "sha256-oAOZa2/m2qs8CeX13/0lmRTg/lQj5aDIaaQeDeLAghc=";
-      excludes = [
-        "azure-pipelines.yml"
-        "buildscripts/azure/azure-windows.yml"
-      ];
-    })
-    # The above doesn't fix the source's build and run time checks of Numpy's
-    # version, it only fixes the tests and API. Upstream puts these checks only
-    # in release tarballs, and hence the patch has to be vendored.
-    ./numpy2.4.patch
-  ]
-  ++ lib.optionals cudaSupport [
+  patches = lib.optionals cudaSupport [
     (replaceVars ./cuda_path.patch {
       cuda_toolkit_path = cudatoolkit;
       cuda_toolkit_lib_path = lib.getLib cudatoolkit;