diff --git a/pkgs/development/python-modules/nltk/default.nix b/pkgs/development/python-modules/nltk/default.nix
index 129b09cd84ff..8d3b7b3dca42 100644
--- a/pkgs/development/python-modules/nltk/default.nix
+++ b/pkgs/development/python-modules/nltk/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   pkgs,
   fetchPypi,
   fetchpatch,
@@ -108,6 +109,11 @@ buildPythonPackage rec {
     "nltk/test/unit/test_downloader.py" # Touches network
   ];
 
+  disabledTests = lib.optionals stdenv.hostPlatform.isDarwin [
+    # ModuleNotFoundError: No module named '_tkinter'
+    "test_chartparser_app_uses_pickle_load_not_pickle_load_standard"
+  ];
+
   pythonImportsCheck = [ "nltk" ];
 
   passthru = {