diff --git a/pkgs/by-name/di/diffoscope/package.nix b/pkgs/by-name/di/diffoscope/package.nix
index b65d2d1e07b4..ef2ec6ae2661 100644
--- a/pkgs/by-name/di/diffoscope/package.nix
+++ b/pkgs/by-name/di/diffoscope/package.nix
@@ -273,6 +273,20 @@ python.pkgs.buildPythonApplication rec {
     "-vv"
   ];
 
+  preCheck = lib.optionalString (enableBloat && stdenv.hostPlatform.isDarwin) ''
+    # h5dump is in hdf5's bin output, but its dylibs are in the out output.
+    export DYLD_LIBRARY_PATH="${lib.makeLibraryPath [ hdf5 ]}''${DYLD_LIBRARY_PATH:+:''${DYLD_LIBRARY_PATH}}"
+  '';
+
+  makeWrapperArgs = lib.optionals enableBloat (
+    [
+      "--prefix PATH : ${lib.makeBinPath [ hdf5 ]}"
+    ]
+    ++ lib.optionals stdenv.hostPlatform.isDarwin [
+      "--prefix DYLD_LIBRARY_PATH : ${lib.makeLibraryPath [ hdf5 ]}"
+    ]
+  );
+
   postInstall = ''
     make -C doc
     installManPage doc/diffoscope.1